Diovan Tablets and Pexidartinib
Determining the interaction of Diovan Tablets and Pexidartinib and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.MONITOR: Coadministration with inhibitors of the hepatic uptake transporter OATP 1B1 (e.g., rifampin, cyclosporine, paritaprevir) or the hepatic efflux transporter MRP2 (e.g., ritonavir) may increase the systemic exposure to valsartan, which is a substrate of both transporters. MANAGEMENT: Caution is advised if valsartan is used in combination with inhibitors of OATP 1B1 or MRP2. Pharmacologic response and blood pressure should be monitored more closely following the addition, discontinuation, or change of dosage of the transporter inhibitor, and the valsartan dosage adjusted as necessary. References "Product Information. Diovan (valsartan)." Novartis Pharmaceuticals, East Hanover, NJ. "Product Information. Viekira Pak (dasabuvir/ombitasvir/paritaprevir/ritonavir)." AbbVie US LLC, North Chicago, IL. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0 "Product Information. Exforge (amlodipine-valsartan)." Novartis Pharmaceuticals, East Hanover, NJ. Cerner Multum, Inc. "Australian Product Information." O 0 View all 5 references
Professional:MONITOR: Coadministration with inhibitors of the hepatic uptake transporter OATP 1B1 (e.g., rifampin, cyclosporine, paritaprevir) or the hepatic efflux transporter MRP2 (e.g., ritonavir) may increase the systemic exposure to valsartan, which is a substrate of both transporters.
MANAGEMENT: Caution is advised if valsartan is used in combination with inhibitors of OATP 1B1 or MRP2. Pharmacologic response and blood pressure should be monitored more closely following the addition, discontinuation, or change of dosage of the transporter inhibitor, and the valsartan dosage adjusted as necessary.
- "Product Information. Diovan (valsartan)." Novartis Pharmaceuticals, East Hanover, NJ.
- "Product Information. Viekira Pak (dasabuvir/ombitasvir/paritaprevir/ritonavir)." AbbVie US LLC, North Chicago, IL.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Exforge (amlodipine-valsartan)." Novartis Pharmaceuticals, East Hanover, NJ.
- Cerner Multum, Inc. "Australian Product Information." O 0
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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