Diphenhydramine and ibuprofen and Mexiletine Hydrochloride

• Generic Name: diphenhydramine / ibuprofen
• Dosage Forms: tablet
• Other Brand Names: Advil PM, Advil PM Liqui-Gels, Ibuprofen PM, Motrin PM

Diphenhydramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Antihistamines can cause drowsiness, which can aid in the treatment of occasional sleep problems (insomnia).

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). Ibuprofen works by reducing hormones that cause inflammation and pain in the body.

Diphenhydramine and ibuprofen is a combination medicine used to treat occasional insomnia associated with minor aches and pains.

Diphenhydramine and ibuprofen is not for use in treating sleeplessness without pain, or sleep problems that occur often.

Diphenhydramine and ibuprofen may also be used for purposes not listed in this medication guide.

• Generic Name: mexiletine
• Dosage Forms: n.a.
• Other Brand Names: Mexitil

Treatment of documented life-threatening ventricular arrhythmias (e.g., sustained ventricular tachycardia). Use for less severe arrhythmias is notrecommended.

Can reduce ventricular premature contractions (VPCs), paired VPCs, and nonsustained ventricular tachycardia and can suppress the recurrence of ventricular tachycardia and/or fibrillation in patients with ventricular tachycardia and/or fibrillation. Avoid treatment of asymptomatic VPCs.

Has been effective in some patients for the treatment of ventricular arrhythmias unresponsive to other antiarrhythmic agents.

Has been used with equivocal results in the management of painful diabetic neuropathy; pending further accumulation of data from well-designed studies, use only in patients who do not respond to or cannot tolerate more established therapies.