Diphenhydramine and Phenylephrine Oral Strips and Dronedarone
Determining the interaction of Diphenhydramine and Phenylephrine Oral Strips and Dronedarone and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.GENERALLY AVOID: The use of higher than recommended dosages of diphenhydramine (e.g., through abuse or misuse) has been associated with serious and potentially fatal cardiac adverse events, including cardiac arrest, and arrhythmia related to prolongation of the QT interval. Coadministration with class Ia (e.g., disopyramide, quinidine, procainamide) and class III (e.g., amiodarone, dofetilide, sotalol) antiarrhythmic agents may result in additive effects and increased risk of ventricular arrhythmias including torsade de pointes and sudden death. In general, the risk of an individual agent or a combination of agents causing ventricular arrhythmia in association with QT prolongation is largely unpredictable but may be increased by certain underlying risk factors such as congenital long QT syndrome, cardiac disease, and electrolyte disturbances (e.g., hypokalemia, hypomagnesemia). In addition, the extent of drug-induced QT prolongation is dependent on the particular drug(s) involved and dosage(s) of the drug(s). MANAGEMENT: Australian authorities recommend avoiding concomitant use of diphenhydramine and class Ia or class III antiarrhythmic agents. Additionally, patients should be counseled to not exceed the recommended dosage and frequency or duration of use of diphenhydramine, and to seek prompt medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, lightheadedness, fainting, palpitation, irregular heart rhythm, shortness of breath, or syncope. References Husain Z, Hussain K, Nair R, Steinman R "Diphenhydramine induced QT prolongation and torsade de pointes: An uncommon effect of a common drug." Cardiology 17 (2010): 509-11 Cerner Multum, Inc. "Australian Product Information." O 0 Shah A, Yousuf T, Ziffra J, Zaidi A, Raghuvir R "Diphenhydramine and QT prolongation - A rare cardiac side effect of a drug used in common practice." J Cardiol Cases 12 (2015): 126-9 Poluzzi E, Raschi E, Godman B, et.al "Pro-arrhythmic potential of oral antihistamines (H1): Combining adverse event reports with drug utilization data across Europe." PLoS One 10 (2014): epub View all 4 references
Professional:GENERALLY AVOID: The use of higher than recommended dosages of diphenhydramine (e.g., through abuse or misuse) has been associated with serious and potentially fatal cardiac adverse events, including cardiac arrest, and arrhythmia related to prolongation of the QT interval. Coadministration with class Ia (e.g., disopyramide, quinidine, procainamide) and class III (e.g., amiodarone, dofetilide, sotalol) antiarrhythmic agents may result in additive effects and increased risk of ventricular arrhythmias including torsade de pointes and sudden death. In general, the risk of an individual agent or a combination of agents causing ventricular arrhythmia in association with QT prolongation is largely unpredictable but may be increased by certain underlying risk factors such as congenital long QT syndrome, cardiac disease, and electrolyte disturbances (e.g., hypokalemia, hypomagnesemia). In addition, the extent of drug-induced QT prolongation is dependent on the particular drug(s) involved and dosage(s) of the drug(s).
MANAGEMENT: Australian authorities recommend avoiding concomitant use of diphenhydramine and class Ia or class III antiarrhythmic agents. Additionally, patients should be counseled to not exceed the recommended dosage and frequency or duration of use of diphenhydramine, and to seek prompt medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, lightheadedness, fainting, palpitation, irregular heart rhythm, shortness of breath, or syncope.
- Husain Z, Hussain K, Nair R, Steinman R "Diphenhydramine induced QT prolongation and torsade de pointes: An uncommon effect of a common drug." Cardiology 17 (2010): 509-11
- Cerner Multum, Inc. "Australian Product Information." O 0
- Shah A, Yousuf T, Ziffra J, Zaidi A, Raghuvir R "Diphenhydramine and QT prolongation - A rare cardiac side effect of a drug used in common practice." J Cardiol Cases 12 (2015): 126-9
- Poluzzi E, Raschi E, Godman B, et.al "Pro-arrhythmic potential of oral antihistamines (H1): Combining adverse event reports with drug utilization data across Europe." PLoS One 10 (2014): epub
Generic Name: diphenhydramine / phenylephrine
Brand name: Children's Triacting Night Time, Delsym Children's Night Time Cough & Cold, Dimetapp Nighttime Cold & Congestion, Dytan-D, PediaCare Children's Allergy & Cold, Robitussin Night Time Cough & Cold, Triaminic Night Time Cold & Cough, Diphentann-D, D-Tann, Uni-Tann D, Aldex-CT, Diphenmax D, Alahist LQ, Robitussin Night Time Cough & Cold Pediatric, Robitussin Night Time Cough & Cold Children's, Delsym Children's Nighttime Cough and Cold, Zoden PD, Benadryl-D Children's Allergy & Sinus, Children's Allergy Plus Congestion, PediaCare Children's NightRest, Children's Triaminic Cough/Cold Nighttime, Theraflu Cold/Cough Nighttime
Synonyms: Diphenhydramine and phenylephrine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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- Diphenhydramine and Phenylephrine Oral Strips-Droperidol Injection
- Diphenhydramine and Phenylephrine Oral Strips-Drospirenone
- Diphenhydramine and Phenylephrine Oral Strips-Drospirenone and estradiol
- Diphenhydramine and Phenylephrine Oral Strips-Drospirenone and ethinyl estradiol
- Dronedarone-Diphenhydramine Capsules
- Dronedarone-Diphenhydramine Capsules and Tablets
- Dronedarone-Diphenhydramine Chewable Tablets and Orally-Disintegrating Tablets
- Dronedarone-Diphenhydramine Elixir, Liquid, and Syrup
- Dronedarone-Diphenhydramine Hydrochloride
- Dronedarone-Diphenhydramine Injection