Diphenoxylate and Atropine Oral Solution and Metoclopramide Hydrochloride
Determining the interaction of Diphenoxylate and Atropine Oral Solution and Metoclopramide Hydrochloride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Atropine may reduce the effects of metoclopramide. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor
Professional:GENERALLY AVOID: Anticholinergic agents and other agents with significant anticholinergic activity (e.g., clozapine, class IA antiarrhythmics especially disopyramide) may antagonize the pharmacologic effects of gastrointestinal prokinetic agents. Gastrokinetic drugs such as domperidone and metoclopramide increase gastrointestinal motility by blocking peripheral dopamine receptors. Anticholinergic agents could negate this action.
MANAGEMENT: Concomitant use of gastrointestinal prokinetic agents with anticholinergic agents should be avoided, if possible.
- "Product Information. Reglan (metoclopramide)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
- "Product Information. Motilium (domperidone)." Janssen-Ortho Inc, Toronto, ON.
Generic Name: atropine / diphenoxylate
Brand name: Lomotil, Lonox, Lomocot, Vi-Atro
Synonyms: Atropine and diphenoxylate, Diphenoxylate and Atropine
Generic Name: metoclopramide
Brand name: Metozolv ODT, Reglan
Synonyms: Metoclopramide
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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