Diphenoxylate and Atropine Oral Solution and Neostigmine Injection
Determining the interaction of Diphenoxylate and Atropine Oral Solution and Neostigmine Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Ask your doctor before using neostigmine together with atropine. Using these medications together can cause increasing muscle weakness. In addition, such use may mask the less serious, gastrointestinal signs of atropine overdose and lead to difficulty breathing, chest pain, and possibly death. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Anticholinergic agents and other agents with significant anticholinergic activity (e.g., clozapine, class IA antiarrhythmics especially disopyramide) may antagonize the effects of cholinergic skeletal muscle stimulants (e.g., ambenonium, edrophonium, guanidine, neostigmine, pyridostigmine). Although this interaction may be desirable in some situations, such as when atropine is used to treat excessive muscarinic side effects and cholinergic crisis induced by anticholinesterase overdose, unintentional or indiscriminate use of anticholinergic agents in the treatment of myasthenia gravis may exacerbate symptoms. In addition, such use may mask the less serious, gastrointestinal signs of cholinergic overdose and lead to inadvertent induction of cholinergic crisis, which can produce respiratory paralysis and death.
MANAGEMENT: Agents with potent anticholinergic activity should preferably be avoided in patients receiving cholinergic skeletal muscle stimulants. If concurrent use is necessary, patients treated for myasthenia gravis should be monitored for potential exacerbation of symptoms. Caution is advised not only because anticholinergic agents may mask the signs of a cholinergic overdose, but also because increasing muscle weakness associated with disease aggravation may be difficult to distinguish from that due to cholinergic crisis.
- "Product Information. Mestinon (pyridostigmine)." ICN Pharmaceuticals Inc, Cost Mesa, CA.
Generic Name: atropine / diphenoxylate
Brand name: Lomotil, Lonox, Lomocot, Vi-Atro
Synonyms: Atropine and diphenoxylate, Diphenoxylate and Atropine
Generic Name: neostigmine
Brand name: Prostigmin, Bloxiverz
Synonyms: Neostigmine Tablets, Neostigmine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Diphenoxylate and Atropine Oral Solution-Neostigmine Methylsulfate
- Diphenoxylate and Atropine Oral Solution-Neostigmine Methylsulfate Injection
- Diphenoxylate and Atropine Oral Solution-Neostigmine Tablets
- Diphenoxylate and Atropine Oral Solution-Nepafenac
- Diphenoxylate and Atropine Oral Solution-Nepafenac Ophthalmic
- Diphenoxylate and Atropine Oral Solution-NephPlex RX
- Neostigmine Injection-Diphenoxylate and Atropine Solution
- Neostigmine Injection-Diphenoxylate and Atropine Tablets
- Neostigmine Injection-Diphenoxylate Hydrochloride
- Neostigmine Injection-Diphtheria & Tetanus Tox, Acell Pertussis, Hep B (Recomb), Polio Vacc
- Neostigmine Injection-Diphtheria & Tetanus Tox/Acell Pertussis/Polio Vacc
- Neostigmine Injection-Diphtheria and Tetanus Toxoids