Diphenoxylate and Atropine Solution and Nitrofurantoin
Determining the interaction of Diphenoxylate and Atropine Solution and Nitrofurantoin and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Anticholinergic agents may increase the absorption and oral bioavailability of nitrofurantoin. The proposed mechanism involves increased gastrointestinal transit time due to reduction of stomach and intestinal motility by anticholinergic agents. In six healthy volunteers, pretreatment with propantheline 45 minutes before a single 100 mg dose of nitrofurantoin significantly increased the oral bioavailability of nitrofurantoin as indicated by a 68% increase in urinary recovery. In another study, atropine 500 mcg given subcutaneously one-half hour before a single 100 mg dose of nitrofurantoin delayed the absorption and urinary excretion of nitrofurantoin but did not affect its overall bioavailability in ten healthy volunteers. The clinical significance of these changes is unknown.
- Mannisto P "The effect of crystal size, gastric content and emptying rate on the absorption of nitrofurantoin in healthy human volunteers." Int J Clin Pharmacol Biopharm 16 (1978): 223-8
- Jaffe JM "Effect of propantheline on nitrofurantoin absorption." J Pharm Sci 64 (1975): 1729-30
Generic Name: atropine / diphenoxylate
Brand name: Lomotil, Lonox, Lomocot, Vi-Atro
Synonyms: Atropine and diphenoxylate, Diphenoxylate and Atropine
Generic Name: nitrofurantoin
Brand name: Furadantin, Macrobid, Macrodantin, Nitro Macro
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Diphenoxylate and Atropine Solution-Nitrofurantoin Capsules
- Diphenoxylate and Atropine Solution-Nitrofurantoin Macrocrystals
- Diphenoxylate and Atropine Solution-Nitrofurantoin Oral Suspension
- Diphenoxylate and Atropine Solution-Nitroglycerin
- Diphenoxylate and Atropine Solution-Nitroglycerin Controlled-Release Capsules
- Diphenoxylate and Atropine Solution-Nitroglycerin Dextrose
- Nitrofurantoin-Diphenoxylate and Atropine Tablets
- Nitrofurantoin-Diphenoxylate Hydrochloride
- Nitrofurantoin-Diphtheria & Tetanus Tox, Acell Pertussis, Hep B (Recomb), Polio Vacc
- Nitrofurantoin-Diphtheria & Tetanus Tox/Acell Pertussis/Polio Vacc
- Nitrofurantoin-Diphtheria and Tetanus Toxoids
- Nitrofurantoin-Diphtheria and Tetanus Toxoids Adsorbed, Tetanus and Diphtheria Toxoids Adsorbed