Diphenoxylate and Atropine Solution and Propulsid (Cisapride Tablets)
Determining the interaction of Diphenoxylate and Atropine Solution and Propulsid (Cisapride Tablets) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Cisapride in no longer on the market in the US. Do not take cisapride with any other medication.
Professional:GENERALLY AVOID: Concomitant administration of anticholinergic agents would be expected to compromise the beneficial effects of cisapride. Cisapride enhances the release of acetylcholine to produce increased gastrointestinal motility. Anticholinergic agents by blocking this action could delay gastric emptying and worsen esophageal reflux.
MANAGEMENT: This combination should be avoided.
- "Product Information. Propulsid (cisapride)." Janssen Pharmaceutica, Titusville, NJ.
Generic Name: atropine / diphenoxylate
Brand name: Lomotil, Lonox, Lomocot, Vi-Atro
Synonyms: Atropine and diphenoxylate, Diphenoxylate and Atropine
Generic Name: cisapride
Brand name: Propulsid
Synonyms: Propulsid (Suspension), Propulsid
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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