Diphenoxylate Hydrochloride and Pralidoxime Chloride
Determining the interaction of Diphenoxylate Hydrochloride and Pralidoxime Chloride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Pralidoxime and other drugs within the family of compounds called oximes, such as obidoxime, may potentiate the pharmacologic effects of atropine. Signs of atropinization such as flushing, mydriasis, tachycardia, and dry mouth and nose may occur earlier than expected during coadministration with pralidoxime relative to administration of atropine alone, particularly if the total dose of atropine has been large and the administration of pralidoxime was delayed. Clinicians should be aware of the potential interaction and monitor patients as appropriate. Pralidoxime may be used in conjunction with atropine in the treatment of organophosphate insecticide poisoning and nerve agent poisoning in terrorism or chemical warfare.
- "Product Information. DuoDote (atropine-pralidoxime)." Meridian Medical Technologies Inc, Columbia, MD.
Generic Name: atropine / diphenoxylate
Brand name: Lomotil, Lonox, Lomocot, Vi-Atro
Synonyms: Atropine and diphenoxylate, Diphenoxylate and Atropine
Generic Name: pralidoxime
Brand name: Protopam Chloride
Synonyms: Pralidoxime
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Diphenoxylate Hydrochloride-Pralidoxime Injection
- Diphenoxylate Hydrochloride-Pramasone
- Diphenoxylate Hydrochloride-PramCort
- Diphenoxylate Hydrochloride-Pramcort Cream
- Diphenoxylate Hydrochloride-Pramipexole
- Diphenoxylate Hydrochloride-Pramipexole Dihydrochloride
- Pralidoxime Chloride-Diphtheria & Tetanus Tox, Acell Pertussis, Hep B (Recomb), Polio Vacc
- Pralidoxime Chloride-Diphtheria & Tetanus Tox/Acell Pertussis/Polio Vacc
- Pralidoxime Chloride-Diphtheria and Tetanus Toxoids
- Pralidoxime Chloride-Diphtheria and Tetanus Toxoids Adsorbed, Tetanus and Diphtheria Toxoids Adsorbed
- Pralidoxime Chloride-Diphtheria and tetanus toxoids vaccine
- Pralidoxime Chloride-Diphtheria and Tetanus Toxoids, Acellular Pertussis, and Poliovirus Vaccine