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Diprivan and Reserpine

Determining the interaction of Diprivan and Reserpine and the possibility of their joint administration.

Check result:
Diprivan <> Reserpine
Relevance: 07.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using propofol together with reserpine may increase the effects of propofol. This can cause increased side effects or cause your condition to change. If your doctor does prescribe these medications together, you may need a dose adjustment or need your blood pressure checked more often to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Rauwolfia alkaloids may accentuate the hypotensive effects of general anesthetics by depleting catecholamine neurotransmitters. Data are conflicting and are available for rauwolfia and reserpine only.

MANAGEMENT: Patients should be closely monitored. If profound hypotension occurs, a direct-acting sympathomimetic agent, such as dobutamine or epinephrine, may be required.

References
  • Jahr JS, Weber S "Ventricular dysrhythmias following an alfentanil anesthetic in a patient on reserpine for hypertension." Acta Anaesthesiol Scand 35 (1991): 788-9
  • Ziegler CH, Lovette JB "Operative complications after therapy with reserpine and reserpine compounds." JAMA 176 (1961): 114-7
Diprivan

Generic Name: propofol

Brand name: Diprivan, Propoven

Synonyms: n.a.

Reserpine

Generic Name: reserpine

Brand name:

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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