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Dipyridamole Injection and Fludarabine

Determining the interaction of Dipyridamole Injection and Fludarabine and the possibility of their joint administration.

Check result:

Dipyridamole Injection <> Fludarabine

Relevance: 20.06.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using dipyridamole together with fludarabine. Using these medications together may decrease the effects of fludarabine. Contact your doctor if your condition worsens. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: The concomitant administration of dipyridamole may theoretically reduce the therapeutic efficacy of fludarabine. Dipyridamole is an adenosine uptake inhibitor and may inhibit the cellular uptake of adenine analogs like fludarabine.

MANAGEMENT: Although clinical data are lacking, it may be advisable to avoid this combination.

References

"Multum Information Services, Inc. Expert Review Panel"
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Dipyridamole Injection

Generic Name: dipyridamole

Brand name: Persantine, Persantine IV

Synonyms: Dipyridamole

What is Dipyridamole Injection?

Fludarabine

Generic Name: fludarabine

Brand name: Fludara, Oforta

Synonyms: Fludarabine (Oral)

What is Fludarabine?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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