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Dipyridamole Injection and Lexiscan

Determining the interaction of Dipyridamole Injection and Lexiscan and the possibility of their joint administration.

Check result:
Dipyridamole Injection <> Lexiscan
Relevance: 20.06.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using dipyridamole together with regadenoson may increase the effects of regadenoson. Contact your doctor if you experience decreased blood pressure and heart rate, heart block, arrhythmias, or any other cardiovascular effects. If possible, dipyridamole should be withheld for at least two days prior to administration of regadenoson for myocardial perfusion imaging. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: Dipyridamole may potentiate the vasodilating effect of regadenoson. Both agents are adenosine receptor agonists, thus a pharmacodynamic interaction may occur during concomitant use. Additive effects are theoretically possible, including hypotension, bradycardia, heart block, arrhythmia, and other cardiovascular effects.

MANAGEMENT: If possible, dipyridamole should be withheld for at least two days prior to administration of regadenoson for myocardial perfusion imaging.

References
  • "Product Information. Lexiscan (regadenoson)." Astellas Pharma US, Inc, Deerfield, IL.
Dipyridamole Injection

Generic Name: dipyridamole

Brand name: Persantine, Persantine IV

Synonyms: Dipyridamole

Lexiscan

Generic Name: regadenoson

Brand name: Lexiscan

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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