Disopyramide Capsules and Ketoconazole (Systemic)

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using disopyramide together with ketoconazole is not recommended. Combining these medications can significantly increase the blood levels of disopyramide. This may increase the risk of serious and potentially life-threatening cardiovascular side effects such as irregular heart rhythm and conduction abnormalities. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Coadministration with potent inhibitors of CYP450 3A4 such as ketoconazole may significantly increase the plasma concentrations of disopyramide, which is primarily metabolized by the isoenzyme. High plasma levels of disopyramide may increase the risk of QT interval prolongation, which has been associated with ventricular arrhythmias including torsade de pointes and sudden death. Ketoconazole itself can also prolong the QT interval, thus an additive pharmacodynamic effect with disopyramide may occur as well.

MANAGEMENT: Coadministration of disopyramide with ketoconazole is considered contraindicated.

Disopyramide Capsules

Generic Name: disopyramide

Brand name: Norpace, Norpace CR

Synonyms: Disopyramide

What is Disopyramide Capsules?

Ketoconazole (Systemic)

Generic Name: ketoconazole

Brand name: Nizoral

Synonyms: Ketoconazole

What is Ketoconazole (Systemic)?