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Disopyramide Capsules and Lanoxin Injection Pediatric

Determining the interaction of Disopyramide Capsules and Lanoxin Injection Pediatric and the possibility of their joint administration.

Check result:

Disopyramide Capsules <> Lanoxin Injection Pediatric

Relevance: 11.04.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Disopyramide may alter the blood levels and effects of digoxin in some patients. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience nausea, vomiting, diarrhea, loss of appetite, visual disturbances (blurred vision; light halos around objects; green or yellow vision), or an abnormally fast or slow or uneven heartbeat, as these may be signs and symptoms of excessive digoxin levels. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Conflicting data indicate a potential interaction between digoxin and disopyramide. Limited data indicate that administration of disopyramide is followed by slightly increased serum digoxin levels, decreased serum half-life, and decreased volume of digoxin distribution. Other data show no significant interaction between disopyramide and digoxin. One study suggests that digoxin may enhance the antiarrhythmic effect of disopyramide by counteracting its potential negative inotropic effect.

MANAGEMENT: During coadministration, the patient should be monitored for digoxin toxicity and serum levels should be checked when necessary. Patients should be advised to notify their physician if they experience signs of digoxin toxicity such as nausea, anorexia, visual disturbances, slow pulse, or irregular heartbeats.

References

Leahey EB, Reiffel JA, Giardina EG, Bigger JT "The effect of quinidine and other oral antiarrhythmic drugs on serum digoxin." Ann Intern Med 92 (1980): 605-8
Risler T, Burk M, Peters U, et al "On the interaction between digoxin and disopyramide." Clin Pharmacol Ther 34 (1983): 176-80
Manolas EG, Hunt D, Sloman G "Effects of quinidine and disopyramide on serum digoxin concentrations." Aust N Z J Med 10 (1980): 426-9
Eliott HL, Kelman AW, Sumner DJ, et al. "Pharmacodynamic and pharmacokinetic evaluation of the interaction between digoxin and disopyramide." Br J Clin Pharmacol 14 (1982): p141
Rodin SM, Johnson BF "Pharmacokinetic interactions with digoxin." Clin Pharmacokinet 15 (1988): 227-44
Garcia-Barreto D, Groning E, Gonzalez-Gomez A, et al "Enhancement of the antiarrhythmic action of disopyramide by digoxin." J Cardiovasc Pharmacol 3 (1981): 1236-42
Lara M, Oakley GD, Rowbotham D "Potentially dangerous effect of disopyramide on atrioventricular conduction in a patient on digitalis." Br Med J July (1980): 198

Disopyramide Capsules

Generic Name: disopyramide

Brand name: Norpace, Norpace CR

Synonyms: Disopyramide

What is Disopyramide Capsules?

Lanoxin Injection Pediatric

Generic Name: digoxin

Brand name: Lanoxin, Digitek, Digox, Lanoxicaps, Cardoxin

Synonyms: Lanoxin

What is Lanoxin Injection Pediatric?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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