Disopyramide Capsules and Timoptic-XE

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using disopyramide together with timolol ophthalmic may have additive effects and possibly cause low blood sugar. Contact your doctor if you experience dizziness, lightheadedness, faint, palpitations, slow or fast pulse, or irregular heartbeats. If your doctor does prescribe these medications together, you may need a dose adjustment or special tests to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Due to its potent negative inotropic and chronotropic effects, disopyramide has been associated with severe hypotension, syncope, severe bradycardia, asystole, and heart failure when used with beta-blockers. Fatalities have been reported. Some beta-blockers have also been reported to decrease the clearance of disopyramide.

MONITOR: The use of disopyramide has been associated with rare cases of significant hypoglycemia. Since beta-blockers may inhibit some of the normal physiologic response to hypoglycemia, glucoregulatory mechanisms (in the absence of food) may be compromised. Specifically, inhibition of catecholamine-mediated glycogenolysis and glucose mobilization in association with beta-blockade can potentiate the hypoglycemia and delay recovery of normal blood glucose levels. In addition, symptoms of hypoglycemia such as tremors and tachycardia may be absent, making it more difficult for patients to recognize an oncoming episode. These effects may be more likely with noncardioselective beta-blockers (e.g., propranolol, pindolol, timolol) but may occasionally also occur with relatively beta-1 selective agents (e.g., atenolol, metoprolol), particularly at higher dosages.

MANAGEMENT: Although the interaction with disopyramide has not been reported when beta-blockers are administered ophthalmically, caution is advised because they are systemically absorbed and can produce clinically significant systemic effects even at low or undetectable plasma levels. Patients should be advised to seek medical attention if they experience dizziness, lightheadedness, syncope, palpitations, slow or fast pulse, or irregular heartbeats.

Disopyramide Capsules

Generic Name: disopyramide

Brand name: Norpace, Norpace CR

Synonyms: Disopyramide

What is Disopyramide Capsules?

Timoptic-XE

Generic Name: timolol ophthalmic

Brand name: Betimol, Istalol, Timoptic Ocudose, Timoptic Ocumeter, Timoptic Ocumeter Plus, Timoptic-XE, Timoptic

Synonyms: Timoptic XE

What is Timoptic-XE?