Disopyramide Capsules and Vardenafil Orally Disintegrating Tablets
Determining the interaction of Disopyramide Capsules and Vardenafil Orally Disintegrating Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Talk to your doctor before using disopyramide together with vardenafil. Combining these drugs can increase the risk of an irregular heart rhythm that may be serious. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats during treatment with these drugs, whether together or alone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Vardenafil has been reported to cause prolongation of the QT interval. Theoretically, coadministration with other agents that can prolong the QT interval may result in additive effects and increased risk of ventricular arrhythmias including torsade de pointes and sudden death. In a study of the effect of vardenafil on QT interval in 59 healthy volunteers, therapeutic (10 mg) and supratherapeutic (80 mg) doses of vardenafil produced similar increases in QTc interval as moxifloxacin 400 mg, the active control.
MANAGEMENT: Patients treated with class IA (e.g., disopyramide, quinidine, procainamide) or class III (e.g., amiodarone, dofetilide, ibutilide, sotalol) antiarrhythmic agents, should avoid using vardenafil.
- "Product Information. Levitra (vardenafil)." Bayer, West Haven, CT.
Generic Name: disopyramide
Brand name: Norpace, Norpace CR
Synonyms: Disopyramide
Generic Name: vardenafil
Brand name: Levitra, Staxyn
Synonyms: Vardenafil
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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