Disopyramide Phosphate and Lidocaine Oropharyngeal Solution
Determining the interaction of Disopyramide Phosphate and Lidocaine Oropharyngeal Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using lidocaine together with disopyramide may have additive effects and can affect the rhythm of your heart. Contact your doctor if you experience tiredness, dizziness, fainting, confusion, tremor, difficulty breathing, and an irregular heartbeat. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: The pharmacologic effects of lidocaine and disopyramide may be additive. The risk of depressed myocardial conduction and contractility may be increased. QT interval prolongation and excessive QRS complex widening may occur with this combination. The risk of arrhythmias, including ventricular tachycardia, fibrillation, and torsades de pointes may be increased.
MANAGEMENT: Patients should be closely monitored for hemodynamic and electrocardiographic evidence of efficacy and toxicity during concomitant administration.
- "Product Information. Norpace (disopyramide)." Searle, Skokie, IL.
- Ellrodt G, Singh BN "Adverse effects of disopyramide (norpace): toxic interactions with other antiarrhythmic agents." Heart Lung 9 (1980): 469-74
Generic Name: disopyramide
Brand name: Norpace, Norpace CR
Synonyms: Disopyramide
Generic Name: lidocaine
Brand name: UAD Caine, Xylocaine HCl, Xylocaine-MPF, Lidoject 1, Xylocaine Dental Cartridges, Lidoject 2, Xylocaine Duo-Trach Kit, Xylocaine HCl For Spinal, L-Caine, Dilocaine, Nervocaine, Truxacaine, Anestacaine
Synonyms: Lidocaine injection, Lidocaine (Systemic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Disopyramide Phosphate-Lidocaine Patch
- Disopyramide Phosphate-Lidocaine Rectal Cream
- Disopyramide Phosphate-Lidocaine Rectal Cream and Gel
- Disopyramide Phosphate-Lidocaine Skin Liquid
- Disopyramide Phosphate-Lidocaine Spray
- Disopyramide Phosphate-Lidocaine topical
- Lidocaine Oropharyngeal Solution-Disopyramide Sustained-Release Capsules
- Lidocaine Oropharyngeal Solution-DisperMox
- Lidocaine Oropharyngeal Solution-Disposable Enema rectal
- Lidocaine Oropharyngeal Solution-Disulfiram
- Lidocaine Oropharyngeal Solution-Dithol Solution
- Lidocaine Oropharyngeal Solution-Ditropan