Disopyramide Phosphate and Pacerone

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using amiodarone together with disopyramide. Combining these medications may occasionally worsen your heart condition or cause serious heart rhythm disturbances. In addition, amiodarone may increase the blood levels and effects of disopyramide, even after you have stopped taking amiodarone for a while. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or fast or pounding heartbeats during treatment with these medications, whether together or alone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration of amiodarone and disopyramide may increase the risk of new arrhythmias due to additive depressant effects on cardiac conduction. There have been reports of torsade de pointes arrhythmia in association with significantly prolonged QT interval ranging from over 500 to 680 msec in patients receiving concomitant therapy. Serious exacerbation of preexisting arrhythmia may also be more likely during coadministration relative to either agent alone. Despite the potential toxicities, amiodarone and disopyramide have been used together successfully in the treatment of certain ventricular arrhythmias.

ADJUST DOSE: Amiodarone is an inhibitor of CYP450 3A4 and may increase the plasma concentrations of disopyramide, which is primarily metabolized by the isoenzyme. Due to the long and variable half-life of amiodarone, potential for interaction may exist even after its discontinuation.

MANAGEMENT: The concurrent use of amiodarone with other antiarrhythmic agents, including disopyramide, should be reserved for patients with life-threatening ventricular arrhythmias who are incompletely responsive to a single agent or to amiodarone alone. In general, if adding or transferring to oral amiodarone, the dosages of previously administered agents should be reduced by 30% to 50% several days after initiation of amiodarone, when onset of arrhythmia suppression is expected to occur. The continued need for other antiarrhythmic agents should be evaluated after the effects of amiodarone have been established, and discontinuation should ordinarily be attempted. If the combination is continued, patients should be monitored closely for adverse effects including conduction disturbances and exacerbation of tachyarrhythmias. Conversely, in amiodarone-treated patients who require additional antiarrhythmic agents, the initial dosage of such agents should be approximately one-half the usual recommended dosage. All patients should be advised to seek medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, lightheadedness, fainting, palpitations, irregular heartbeat, shortness of breath, or syncope.

Disopyramide Phosphate

Generic Name: disopyramide

Brand name: Norpace, Norpace CR

Synonyms: Disopyramide

What is Disopyramide Phosphate?

Pacerone

Generic Name: amiodarone

Brand name: Pacerone, Cordarone, Nexterone

Synonyms: n.a.

What is Pacerone?