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Disopyramide Phosphate and Sporanox PulsePak

Determining the interaction of Disopyramide Phosphate and Sporanox PulsePak and the possibility of their joint administration.

Check result:

Disopyramide Phosphate <> Sporanox PulsePak

Relevance: 12.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using disopyramide together with itraconazole is not recommended. Combining these medications can significantly increase the blood levels of disopyramide. This may increase the risk of serious and potentially life-threatening cardiovascular side effects such as irregular heart rhythm and conduction abnormalities. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: Coadministration with potent inhibitors of CYP450 3A4 such as itraconazole may significantly increase the plasma concentrations of disopyramide, which is primarily metabolized by the isoenzyme. High plasma levels of disopyramide may increase the risk of QT interval prolongation, which has been associated with ventricular arrhythmias including torsade de pointes and sudden death. Rarely, azole antifungal agents have also been reported to prolong the QT interval, thus an additive pharmacodynamic effect with disopyramide may occur as well.

MANAGEMENT: Coadministration of disopyramide with itraconazole is considered contraindicated.

References

Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
"Product Information. Norpace (disopyramide)." Searle, Skokie, IL.
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
"Product Information. Sporonox (itraconazole)." Janssen Pharmaceutica, Titusville, NJ.

Disopyramide Phosphate

Generic Name: disopyramide

Brand name: Norpace, Norpace CR

Synonyms: Disopyramide

What is Disopyramide Phosphate?

Sporanox PulsePak

Generic Name: itraconazole

Brand name: Sporanox, Onmel, Sporanox PulsePak, Tolsura

Synonyms: Sporanox

What is Sporanox PulsePak?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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