Disopyramide Phosphate and Ziconotide

• Generic Name: disopyramide
• Dosage Forms: n.a.
• Other Brand Names: Norpace, Norpace CR

Precise role in antiarrhythmic therapy has not been established. Some experts recommend that disopyramide be reserved for use as an alternative drug when lidocaine, quinidine, or procainamide is ineffective or adverse effects of these drugs are intolerable.

Limited information is available on combination therapy with other antiarrhythmic drugs such as lidocaine, quinidine, or procainamide to treat or prevent serious, refractory arrhythmias.

Suppression and prevention of recurrent life-threatening ventricular arrhythmias (e.g., sustained VT). (See Boxed Warning.)

Because of disopyramide’s arrhythmogenic potential and lack of evidence for improved survival for class I antiarrhythmic agents, use for less severe arrhythmias is not recommended.

Avoid treatment of asymptomatic VPCs.

Has been used to convert atrial fibrillation, atrial flutter, and paroxysmal atrial tachycardia to normal sinus rhythm. However, other antiarrhythmic drugs (e.g., dofetilide, flecainide, ibutilide, propafenone, amiodarone) are preferred.

• Generic Name: ziconotide
• Dosage Forms: n.a.
• Other Brand Names: Prialt

Ziconotide is a non-narcotic pain reliever that works by blocking pain signals from the nerves to the brain.

Ziconotide is used to treat severe chronic pain in people who cannot use or do not respond to standard pain-relieving medications.

Ziconotide may also be used for other purposes not listed in this medication guide.