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Disopyramide Sustained-Release Capsules and Phenytoin Sodium

Determining the interaction of Disopyramide Sustained-Release Capsules and Phenytoin Sodium and the possibility of their joint administration.

Check result:

Disopyramide Sustained-Release Capsules <> Phenytoin Sodium

Relevance: 14.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using phenytoin together with disopyramide may decrease the effects of disopyramide. Contact your doctor if your condition changes or if you experience dry mouth, blurry vision, urinary retention, or a worsening of an irregular heartbeat. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Phenytoin may decrease plasma levels and therapeutic effects of disopyramide. The mechanism may be related to induction of CYP450 disopyramide metabolism. In one study, the disopyramide AUC was decreased by 52% and the half-life by 51%. Other hydantoins also may participate in this interaction.

MANAGEMENT: If disopyramide and a hydantoin must be used together, close observation for evidence of altered disopyramide effect is recommended. An alternative to disopyramide should be considered if increased anticholinergic effects (due to increased concentrations of its metabolite) occur. Patients should be advised to notify their physician if they experience dry mouth, blurry vision, urinary retention, or a worsening of their irregular heartbeat.

References

Nightingale J, Nappi JM "Effect of phenytoin on serum disopyramide concentrations." Clin Pharm 6 (1987): 46-50
Aitio ML, Vuorenmaa T "Enhanced metabolism and diminished efficacy of disopyramide by enzyme induction?" Br J Clin Pharmacol 9 (1980): 149-52
Ellrodt G, Singh BN "Adverse effects of disopyramide (norpace): toxic interactions with other antiarrhythmic agents." Heart Lung 9 (1980): 469-74
Aitio ML, Mansury L, Tala E, et al "The effect of enzyme induction on the metabolism of disopyramide in man." Br J Clin Pharmacol 11 (1981): 279-85

Disopyramide Sustained-Release Capsules

Generic Name: disopyramide

Brand name: Norpace, Norpace CR

Synonyms: Disopyramide

What is Disopyramide Sustained-Release Capsules?

Phenytoin Sodium

Generic Name: phenytoin

Brand name: Dilantin, Dilantin Infatabs, Phenytek, Phenytoin Sodium, Prompt

Synonyms: n.a.

What is Phenytoin Sodium?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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