Drug search by name

Disulfiram and Flagyl

Determining the interaction of Disulfiram and Flagyl and the possibility of their joint administration.

Check result:

Disulfiram <> Flagyl

Relevance: 08.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using disulfiram together with metroNIDAZOLE is not recommended. Combining these medications may cause confusion and psychotic reactions such as delusions and hallucinations in some patients. You should generally not use metroNIDAZOLE if you have taken disulfiram within the last two weeks. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: Use of a nitroimidazole in patients treated with disulfiram may result in psychotic reactions. The exact mechanism of interaction is unknown, but may involve additive effects on aldehyde dehydrogenase (ALDH) inhibition. The interaction has been reported with metronidazole. In one study, 6 of 29 hospitalized alcoholic patients who were treated with disulfiram (500 mg daily for one month, then 250 mg daily) and metronidazole (750 mg daily for one month, then 250 mg daily) developed acute psychoses or a confusional state, compared to none of the 29 patients receiving disulfiram alone. Five had paranoid delusions and three had visual and auditory hallucinations. Symptoms initially increased following withdrawal of the medications, but resolved slowly over two weeks and did not recur when disulfiram alone was restarted. No data are available for other nitroimidazoles or vaginally administered metronidazole.

MANAGEMENT: Nitroimidazole therapy should not be administered with disulfiram. Metronidazole and benznidazole are specifically contraindicated in patients who have taken disulfiram within the last two weeks according to their product labeling.

References

Knee ST, Razani J "Acute organic brain syndrome: a complication of disulfiram therapy." Am J Psychiatry 131 (1974): 1281-2
"Product Information. Flagyl (metronidazole)." Searle, Skokie, IL.
Scher JM "Psychotic reaction to disulfiram." JAMA 201 (1967): 175
Rothstein E, Clancy DD "Toxicity of disulfiram combined with metronidazole." N Engl J Med 280 (1969): 1006-7
"Product Information. Benznidazole (benznidazole)." Everett Laboratories Inc, West Orange, NJ.
"Product Information. Metrogel-Vaginal (metronidazole)." Curatek Pharmaceuticals Ltd, Elk Grove Village, IL.

Disulfiram

Generic Name: disulfiram

Brand name: Antabuse

Synonyms: n.a.

What is Disulfiram?

Flagyl

Generic Name: metronidazole

Brand name: Flagyl, FIRST Metronidazole, Flagyl 375, MetroGel

Synonyms: n.a.

What is Flagyl?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions