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Disulfiram and Pms-Isoniazid

Determining the interaction of Disulfiram and Pms-Isoniazid and the possibility of their joint administration.

Check result:

Disulfiram <> Pms-Isoniazid

Relevance: 08.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using isoniazid together with disulfiram may lead to increased side effects. Contact your doctor if you experience drowsiness, loss of muscle coordination, mood changes or behavioral changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Isoniazid and disulfiram taken together have been reported to cause acute changes in behavior and coordination. The mechanism may be related to excess dopaminergic activity due to inhibition of metabolic pathways for dopamine by both drugs.

MANAGEMENT: If these agents must be coadministered, the clinician should consider monitoring the patient closely for altered mental status (drowsiness, ataxia, mood changes or behavioral changes). Disulfiram should be discontinued or the dosage reduced if an interaction is suspected.

References

Whittington HG, Grey L "Possible interaction between disulfiram and isoniazid." Am J Psychiatry 125 (1969): 1725-9

Disulfiram

Generic Name: disulfiram

Brand name: Antabuse

Synonyms: n.a.

What is Disulfiram?

Pms-Isoniazid

Generic Name: isoniazid

Brand name: Nydrazid

Synonyms: Isoniazid

What is Pms-Isoniazid?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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