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Disulfiram and Sertraline Hydrochloride

Determining the interaction of Disulfiram and Sertraline Hydrochloride and the possibility of their joint administration.

Check result:

Disulfiram <> Sertraline Hydrochloride

Relevance: 08.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using sertraline and disulfiram is not recommended. The oral solution contains alcohol. When alcohol is combined with disulfiram there is a possibility of side effects such as flushing, headache, nausea, vomiting, sweating, and thirst. It is recommended to not use drugs with alcohol in them while taking disulfiram. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: Sertraline oral concentrate contains 12% alcohol and may cause an interaction with disulfiram. Disulfiram is an irreversible inhibitor of aldehyde dehydrogenase (ALDH). Following ingestion of alcohol, the inhibition of ALDH results in increased concentration of acetaldehyde, the accumulation of which produces an unpleasant physiologic response referred to as the 'disulfiram reaction'. Symptoms include flushing, throbbing in head and neck, throbbing headache, respiratory difficulty, nausea, vomiting, sweating, thirst, chest pain, palpitation, dyspnea, hyperventilation, tachycardia, hypotension, syncope, weakness, vertigo, blurred vision, and confusion. Severe reactions may result in respiratory depression, cardiovascular collapse, arrhythmias, myocardial infarction, acute congestive heart failure, unconsciousness, convulsions, and death.

MANAGEMENT: The use of sertraline oral concentrate with disulfiram is considered contraindicated. A different formulation of sertraline or another selective serotonin reuptake inhibitor should be prescribed in patients receiving therapy with disulfiram.

References

"Product Information. Antabuse (disulfiram)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
"Product Information. Zoloft (sertraline)." Roerig Division, New York, NY.

Disulfiram

Generic Name: disulfiram

Brand name: Antabuse

Synonyms: n.a.

What is Disulfiram?

Sertraline Hydrochloride

Generic Name: sertraline

Brand name: Zoloft

Synonyms: Sertraline

What is Sertraline Hydrochloride?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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