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Disulfiram and Silenor

Determining the interaction of Disulfiram and Silenor and the possibility of their joint administration.

Check result:

Disulfiram <> Silenor

Relevance: 08.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

The combination of disulfiram and tricyclic antidepressants may reportedly result in acute organic brain syndrome or dementia. The mechanism is unknown and causality has not been definitely established. Patients should be monitored for symptoms of an interaction.

References

MacCallum WA "Drug interactions in alcoholism treatment." Lancet 1 (1969): 313
Maany I, Hayashida M, Pfeffer SL, Kron RE "Possible toxic interaction between disulfiram and amitriptyline." Arch Gen Psychiatry 39 (1982): 743-4

Disulfiram

Generic Name: disulfiram

Brand name: Antabuse

Synonyms: n.a.

What is Disulfiram?

Silenor

Generic Name: doxepin

Brand name: Silenor, Sinequan, Sinequan

Synonyms: n.a.

What is Silenor?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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