Disulfiram and Tipranavir

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ask your doctor before using disulfiram together with tipranavir. Tipranavir capsules contain alcohol, which can produce severe reactions when taken with disulfiram. This can cause flushing, fast heartbeats, nausea, thirst, chest pain, vertigo, and low blood pressure. Be aware of the alcohol content of other common products such as cough and cold medicines, mouth washes, tonics, sauces, vinegars, and other food products. Alcohol in these products can also cause a reaction with disulfiram. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Tipranavir capsules contain alcohol, which can produce severe reactions when coadministered with disulfiram. The mechanism is inhibition of aldehyde dehydrogenase (ALDH) by disulfiram. Following ingestion of alcohol, inhibition of ALDH results in increased concentration of acetaldehyde, the accumulation of which produces an unpleasant physiologic response referred to as the 'disulfiram reaction'. Symptoms include flushing, throbbing in head and neck, throbbing headache, respiratory difficulty, nausea, vomiting, sweating, thirst, chest pain, palpitation, dyspnea, hyperventilation, tachycardia, hypotension, syncope, weakness, vertigo, blurred vision, and confusion. Severe reactions may result in respiratory depression, cardiovascular collapse, arrhythmias, myocardial infarction, acute congestive heart failure, unconsciousness, convulsions, and death.

MANAGEMENT: Concomitant use of tipranavir capsules and disulfiram should be avoided.

Disulfiram

Generic Name: disulfiram

Brand name: Antabuse

Synonyms: n.a.

What is Disulfiram?

Tipranavir

Generic Name: tipranavir

Brand name: Aptivus

Synonyms: n.a.

What is Tipranavir?