Diuril (Chlorothiazide Injection) and Doxycycline Delayed-Release Tablets
Determining the interaction of Diuril (Chlorothiazide Injection) and Doxycycline Delayed-Release Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:The coadministration of diuretics and tetracyclines may result in decreased renal function manifested by increases in serum creatinine and blood urea nitrogen (BUN). Usually, no clinical intervention is necessary, unless decreases in renal function occur. If renal function deteriorates, discontinuation of one or both agents may be necessary.
- Garty M, Hurwitz A "Effect of cimetidine and antacids on gastrointestinal absorption of tetracycline." Clin Pharmacol Ther 28 (1980): 203-7
- Tannenberg AM "Tetracycline and rises in urea nitrogen." JAMA 221 (1972): 713
- Jick H, Slone D, Shapiro S, et al "Tetracycline and drug-attributed rises in blood urea nitrogen: a report from the Boston Collaborative Drug Surveillance Program." JAMA 220 (1972): 377-9
- Alexander MR "Tetracycline and rises in urea nitrogen." JAMA 221 (1972): 713-4
Generic Name: chlorothiazide
Brand name: Diuril, Diuril Sodium
Synonyms: Diuril (oral/injection), Diuril
Generic Name: doxycycline
Brand name: Acticlate, Adoxa CK, Adoxa Pak, Adoxa TT, Alodox, Avidoxy, Doryx, Mondoxyne NL, Monodox, Morgidox, Oracea, Oraxyl, Periostat Targadox, Vibramycin Calcium, Vibramycin Hyclate, Vibramycin monohydrate, Vibra-Tabs, Adox Pak 2/100, Adoxa, Adoxa Pak 1/100, Adoxa Pak 1/150, Avidoxy, TargaDOX, Vibramycin, Doxy 100, TargaDOX
Synonyms: Doxycycline
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Diuril (Chlorothiazide Injection)-Doxycycline Hyclate
- Diuril (Chlorothiazide Injection)-Doxycycline Hyclate Delayed Release
- Diuril (Chlorothiazide Injection)-Doxycycline Hyclate eent
- Diuril (Chlorothiazide Injection)-Doxycycline Hyclate Tablets
- Diuril (Chlorothiazide Injection)-Doxycycline Injection
- Diuril (Chlorothiazide Injection)-Doxycycline Monohydrate
- Doxycycline Delayed-Release Tablets-Diuril (Chlorothiazide Suspension)
- Doxycycline Delayed-Release Tablets-Diuril Injection
- Doxycycline Delayed-Release Tablets-Diuril oral/injection
- Doxycycline Delayed-Release Tablets-Diuril Sodium
- Doxycycline Delayed-Release Tablets-Divalproex
- Doxycycline Delayed-Release Tablets-Divalproex Capsules