Diuril (Chlorothiazide Suspension) and Hyoscyamine Sulfate Elixir
Determining the interaction of Diuril (Chlorothiazide Suspension) and Hyoscyamine Sulfate Elixir and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Anticholinergic agents may increase the absorption and oral bioavailability of thiazide diuretics. The proposed mechanism involves increased gastrointestinal transit time due to reduction of stomach and intestinal motility by anticholinergic agents. In six healthy volunteers, pretreatment with propantheline prolonged the time to reach peak plasma concentration (Tmax) for hydrochlorothiazide from 2.4 to 4.8 hours and increased its total 48-hour urinary recovery by 36%. Similar results were reported for chlorothiazide in another study. The clinical significance of these changes is unknown.
- Osman MA, Welling PG "Influence of propantheline and metoclopramide on the bioavailability of chlorothiazide." Curr Ther Res Clin Exp 34 (1983): 404-8
- Beermann B, Groschinsky-Grind M "Enhancement of the gastrointestinal absorption of hydrochlorothiazide by propantheline." Eur J Clin Pharmacol 13 (1978): 385-7
Generic Name: chlorothiazide
Brand name: Diuril, Diuril Sodium
Synonyms: Diuril (oral/injection), Diuril
Generic Name: hyoscyamine
Brand name: Anaspaz, Ed Spaz, Hyosyne, Levbid, Levsin, NuLev, Symax SR, Cystospaz, Levsin SL, Cystospaz-M, Levsinex SR, Symax SL, A-Spas S/L, Donnamar, Hyosol, NuLev, Spasdel, IB-Stat, Hyospaz, Symax Duotab, Symax FasTab, HyoMax SL, HyoMax SR, HyoMax FT, HyoMax DT, HyoMax, Oscimin, A-Spaz, Levsin/SL, Colidrops, Levsinex, Symax, Symax FasTabs
Synonyms: Hyoscyamine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Diuril (Chlorothiazide Suspension)-Hyoscyamine Sulfate Extended-Release Tablets
- Diuril (Chlorothiazide Suspension)-Hyoscyamine Sulfate Oral Drops
- Diuril (Chlorothiazide Suspension)-Hyoscyamine Sulfate Orally Disintegrating Tablet
- Diuril (Chlorothiazide Suspension)-Hyoscyamine Sulfate Sublingual Tablet
- Diuril (Chlorothiazide Suspension)-Hyoscyamine Sulfate Tablet
- Diuril (Chlorothiazide Suspension)-Hyoscyamine Tablets
- Hyoscyamine Sulfate Elixir-Diuril Injection
- Hyoscyamine Sulfate Elixir-Diuril oral/injection
- Hyoscyamine Sulfate Elixir-Diuril Sodium
- Hyoscyamine Sulfate Elixir-Divalproex
- Hyoscyamine Sulfate Elixir-Divalproex Capsules
- Hyoscyamine Sulfate Elixir-Divalproex Delayed Release