Diuril (Chlorothiazide Suspension) and Levulan
Determining the interaction of Diuril (Chlorothiazide Suspension) and Levulan and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Aminolevulinic acid topical may cause your skin to be more sensitive to light in areas where it has been applied. The risk and/or severity of reactions such as redness, scaling, swelling, stinging, and burning may be increased when it is used with other drugs that also increase sensitivity to light such as chlorothiazide. You should avoid exposure to sunlight or bright indoor lights (examination lamps, operating room lamps, tanning beds, lights at close proximity) during treatment as directed by your doctor. Since sunscreens will not protect you against photosensitivity reactions associated with aminolevulinic acid topical, you should protect treated areas prior to the light treatment at your doctor's office by wearing a wide-brimmed hat or other protective apparel if exposure to sunlight or other intense lights cannot be avoided. Be advised to reduce your light exposure if you experience sensations of stinging and/or burning. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Concomitant use of aminolevulinate topical preparations with other known photosensitizing agents may enhance the phototoxic reaction to photodynamic therapy. Medicinal products with known phototoxic or photoallergic potential include fluoroquinolones, phenothiazines, retinoids, sulfonamides, sulfonylureas, tetracyclines, thiazide diuretics, griseofulvin, and hypericin extracts (e.g., St John's Wort).
MANAGEMENT: Caution is advised and pharmacologic response to photodynamic therapy should be carefully monitored if concomitant use of other photosensitizing agents cannot be avoided. Patients should be advised to avoid exposure of treated areas to sunlight or bright indoor lights (e.g., examination lamps, operating room lamps, tanning beds, lights at close proximity) during the period between application of aminolevulinic acid or methyl aminolevulinate and photoactivation, and for 48 hours post-illumination. Concomitant use with other topical medicinal products should be avoided. Some authorities recommend avoiding use of hypericin-containing products for 2 weeks prior to treatment with topical aminolevulinic acid.
- Cerner Multum, Inc. "Australian Product Information." O 0
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Metvixia (methyl aminolevulinate topical)." Galderma Laboratories Inc, Cranbury, NJ.
- "Product Information. Levulan Kerastick (aminolevulinic acid)" Berlex, Richmond, CA.
Generic Name: chlorothiazide
Brand name: Diuril, Diuril Sodium
Synonyms: Diuril (oral/injection), Diuril
Generic Name: aminolevulinic acid topical
Brand name: Ameluz, Levulan Kerastick
Synonyms: Levulan Kerastick (topical), Levulan Kerastick
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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