Diuril (Chlorothiazide Suspension) and Timolol eent
Determining the interaction of Diuril (Chlorothiazide Suspension) and Timolol eent and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using chlorothiazide and timolol ophthalmic together may lower your blood pressure and slow your heart rate. This can cause dizziness, or feeling like you might pass out, weakness, fainting, fast or irregular heartbeats, or loss of blood glucose control. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or need your blood pressure checked more often to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Although they are often combined in clinical practice, diuretics and beta-blockers may increase the risk of hyperglycemia and hypertriglyceridemia in some patients, especially in patients with diabetes or latent diabetes. In addition, the risk of QT interval prolongation and arrhythmias (e.g. torsades de pointes) due to sotalol may be increased by potassium-depleting diuretics.
MANAGEMENT: Monitoring of serum potassium levels, blood pressure, and blood glucose is recommended during coadministration. Patients should be advised to seek medical assistance if they experience dizziness, weakness, fainting, fast or irregular heartbeats, or loss of blood glucose control.
- Dean S, Kendall MJ, Potter S, Thompson MH, Jackson DA "Nadolol in combination with indapamide and xipamide in resistant hypertensives." Eur J Clin Pharmacol 28 (1985): 29-33
- Dornhorst A, Powell SH, Pensky J "Aggravation by propranolol of hyperglycaemic effect of hydrochlorothiazide in type II diabetics without alteration of insulin secretion." Lancet 1 (1985): 123-6
- "Product Information. Lozol (indapamide)." Rhone-Poulenc Rorer, Collegeville, PA.
- Marcy TR, Ripley TL "Aldosterone antagonists in the treatment of heart failure." Am J Health Syst Pharm 63 (2006): 49-58
- Roux A, Le Liboux A, Delhotal B, Gaillot J, Flouvat B "Pharmacokinetics in man of acebutolol and hydrochlorothiazide as single agents and in combination." Eur J Clin Pharmacol 24 (1983): 801-6
Generic Name: chlorothiazide
Brand name: Diuril, Diuril Sodium
Synonyms: Diuril (oral/injection), Diuril
Generic Name: timolol ophthalmic
Brand name: Betimol, Istalol, Timoptic Ocudose, Timoptic Ocumeter, Timoptic Ocumeter Plus, Timoptic-XE, Timoptic
Synonyms: Timolol ophthalmic, Timolol (Ophthalmic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Diuril (Chlorothiazide Suspension)-Timolol Eye Drops (Bottle)
- Diuril (Chlorothiazide Suspension)-Timolol Gel Eye Drops
- Diuril (Chlorothiazide Suspension)-Timolol GFS
- Diuril (Chlorothiazide Suspension)-Timolol Maleate
- Diuril (Chlorothiazide Suspension)-Timolol ophthalmic
- Diuril (Chlorothiazide Suspension)-Timolol Unit Dose Eye Drops
- Timolol eent-Diuril Injection
- Timolol eent-Diuril oral/injection
- Timolol eent-Diuril Sodium
- Timolol eent-Divalproex
- Timolol eent-Divalproex Capsules
- Timolol eent-Divalproex Delayed Release