Divalproex and Felbamate Oral Suspension

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using divalproex sodium together with felbamate may increase the effects of divalproex sodium. Contact your doctor if you experience side effects such as nausea, confusion, irritability, nervousness, restlessness, tremor, insomnia, headache, or drowsiness. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Felbamate may increase steady-state plasma concentrations of valproate by decreasing its plasma clearance. In a study involving 10 patients with epilepsy, valproate mean peak concentrations increased by 34% and 55% when coadministered with felbamate at doses of 1200 mg/day and 2400 mg/day, respectively. In another study involving 4 patients with epilepsy, valproate steady-state minimum concentrations increased by 24% and 52% when coadministered with felbamate at doses of 1200 mg/day and 2400 mg/day, respectively. Valproate protein binding did not change significantly with increasing doses of felbamate.

MANAGEMENT: When combination therapy involving felbamate and valproic acid or its derivatives is initiated, valproate dosage generally should be decreased 20% to 30%. Lower felbamate dosages may also be required. Close observation for clinical and laboratory evidence of altered effects is indicated, especially when changing the dose or discontinuing felbamate. Patients should be advised to report possible symptoms of valproate toxicity to their physician, including nausea, confusion, irritability, nervousness, restlessness, tremor, insomnia, headache, or somnolence.

Divalproex

Generic Name: divalproex sodium

Brand name: Depakote ER, Depakote Sprinkles, Depakote, Depakene, Depacon

Synonyms: Divalproex sodium

What is Divalproex?

Felbamate Oral Suspension

Generic Name: felbamate

Brand name: Felbatol

Synonyms: Felbamate

What is Felbamate Oral Suspension?