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Divalproex and Klonopin Wafers

Determining the interaction of Divalproex and Klonopin Wafers and the possibility of their joint administration.

Check result:

Divalproex <> Klonopin Wafers

Relevance: 25.04.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before taking clonazePAM, tell your doctor if you also use divalproex sodium. You may need dose adjustments or special tests in order to safely take both medications together. This combination may affect seizure control and cause drowsiness. You should avoid driving until you know how these medications will affect you. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

Professional:

MONITOR: A single study has suggested that combination therapy with clonazepam and valproic acid may cause severe drowsiness and decreased seizure control. Other studies have not supported this finding. Several case reports have suggested that the combination of clonazepam and valproic acid may precipitate absence status; however, this combination has had beneficial effects in the treatment refractory absence seizures. The mechanism and causality have not been determined. In addition, valproic acid may decrease plasma levels of clonazepam by inducing its hepatic metabolism.

MANAGEMENT: Monitoring for altered efficacy and safety is recommended if valproic acid (or its derivatives) and clonazepam are used together. Alternative therapy may be appropriate if significant side effects or loss of seizure control occur.

References

Watson WA "Interaction between clonazepam and sodium valproate." N Engl J Med 300 (1979): 678-9
Jeavons PM, Clark JE, Maheshwari MC "Treatment of generalized epilepsies of childhood and adolescence with sodium valproate("epilim")." Dev Med Child Neurol 19 (1977): 9-25
Watson B "Absence status and the concurrent administration of clonazepam and valproate sodium." Am J Hosp Pharm 36 (1979): 887
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Wilder BJ, Willmore LJ, Bruni J, Villarreal HJ "Valproic acid: interaction with other anticonvulsant drugs." Neurology 28 (1978): 892-6
"Product Information. Klonopin (clonazepam)." Roche Laboratories, Nutley, NJ.

Divalproex

Generic Name: divalproex sodium

Brand name: Depakote ER, Depakote Sprinkles, Depakote, Depakene, Depacon

Synonyms: Divalproex sodium

What is Divalproex?

Klonopin Wafers

Generic Name: clonazepam

Brand name: Klonopin Wafer, Klonopin

Synonyms: Klonopin Wafer

What is Klonopin Wafers?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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