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Divalproex and Propofol

Determining the interaction of Divalproex and Propofol and the possibility of their joint administration.

Check result:

Divalproex <> Propofol

Relevance: 25.04.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Divalproex sodium may increase the blood levels and effects of propofol. You may need a dose adjustment or closer monitoring during the procedure to safely use both medications. Before undergoing anesthesia, let your doctor if you are receiving treatment with divalproex sodium. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with valproate may increase the blood levels of propofol. The mechanism may involve inhibition of propofol clearance via glucuronidation, as valproate is known to be an inhibitor of glucuronosyltransferases.

MANAGEMENT: Dosage reduction of propofol may be required when coadministered with valproate. Patients should be closely monitored for signs of increased sedation and cardiorespiratory depression.

References

"Product Information. Depacon (valproic acid)." Abbott Pharmaceutical, Abbott Park, IL.
"Product Information. Depakene (valproic acid)." Abbott Pharmaceutical, Abbott Park, IL.
"Product Information. Depakote (divalproex sodium)." Abbott Pharmaceutical, Abbott Park, IL.
"Product Information. Diprivan (propofol)." Zeneca Pharmaceuticals, Wilmington, DE.

Divalproex

Generic Name: divalproex sodium

Brand name: Depakote ER, Depakote Sprinkles, Depakote, Depakene, Depacon

Synonyms: Divalproex sodium

What is Divalproex?

Propofol

Generic Name: propofol

Brand name: Diprivan, Propoven

Synonyms: n.a.

What is Propofol?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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