Divalproex and Rufinamide

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Divalproex sodium may increase the blood levels of rufinamide. In some cases, this may increase side effects such as drowsiness, dizziness, fatigue, incoordination, nausea, vomiting, and low white blood cell count. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the interaction, but has determined that this is the best course of treatment for you and has taken appropriate precautions or made dose adjustments and is monitoring you closely for any potential complications. Your doctor may also be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Coadministration with valproate may increase the plasma concentrations of rufinamide. The mechanism of interaction has not been established. According to a population pharmacokinetic analysis, rufinamide steady-state concentrations increased by less than 16% up to 70% depending on concomitant plasma valproate concentration. The largest increases were reported in pediatric patients or patients of low body weight (

Divalproex

Generic Name: divalproex sodium

Brand name: Depakote ER, Depakote Sprinkles, Depakote, Depakene, Depacon

Synonyms: Divalproex sodium

What is Divalproex?

Rufinamide

Generic Name: rufinamide

Brand name: Banzel

Synonyms: n.a.

What is Rufinamide?