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Divalproex and Sodium phenylbutyrate

Determining the interaction of Divalproex and Sodium phenylbutyrate and the possibility of their joint administration.

Check result:

Divalproex <> Sodium phenylbutyrate

Relevance: 25.04.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Talk to your doctor before using divalproex sodium together with sodium phenylbutyrate. Divalproex sodium can increase ammonia levels in the blood and is generally not recommended for patients with urea cycle disorders. You may need a dosage adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: Valproic acid can increase plasma ammonia levels and may interfere with the therapeutic effects of phenylbutyrate therapy in the management of urea cycle disorders. Hyperammonemic encephalopathy, sometimes fatal, has been reported following initiation of valproate therapy in patients with urea cycle disorders, particularly ornithine transcarbamylase deficiency.

MANAGEMENT: Valproic acid should generally not be given to patients receiving phenylbutyrate therapy, as the use of valproic acid is considered contraindicated in patients with urea cycle disorders.

References

"Product Information. Depakene (valproic acid)." Abbott Pharmaceutical, Abbott Park, IL.
"Product Information. Depakote (divalproex sodium)." Abbott Pharmaceutical, Abbott Park, IL.
"Product Information. Buphenyl (sodium phenylbutyrate)." Horizon Pharma USA Inc, Northbrook, IL.
"Product Information. Ravicti (glycerol phenylbutyrate)." Hyperion Therapeutics Inc, South San Francisco, CA.

Divalproex

Generic Name: divalproex sodium

Brand name: Depakote ER, Depakote Sprinkles, Depakote, Depakene, Depacon

Synonyms: Divalproex sodium

What is Divalproex?

Sodium phenylbutyrate

Generic Name: sodium phenylbutyrate

Brand name: Buphenyl

Synonyms: Sodium Phenylbutyrate Powder

What is Sodium phenylbutyrate?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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