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Divalproex and Tagamet HB

Determining the interaction of Divalproex and Tagamet HB and the possibility of their joint administration.

Check result:

Divalproex <> Tagamet HB

Relevance: 25.04.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Cimetidine may inhibit the hepatic metabolism of valproate. Reductions in valproate clearance of 2% to 17% have been reported. The clinical significance of this interaction is unknown. The interaction may be most significant in patients with serum valproic acid levels near the upper limit of the therapeutic range.

References

Webster LK, Mihaly GW, Jones DB, et al "Effect of cimetidine and ranitidine on carbamazepine and sodium valproate pharmacokinetics." Eur J Clin Pharmacol 27 (1984): 341-3

Divalproex

Generic Name: divalproex sodium

Brand name: Depakote ER, Depakote Sprinkles, Depakote, Depakene, Depacon

Synonyms: Divalproex sodium

What is Divalproex?

Tagamet HB

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: n.a.

What is Tagamet HB?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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