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Divalproex and Tiagabine Hydrochloride

Determining the interaction of Divalproex and Tiagabine Hydrochloride and the possibility of their joint administration.

Check result:
Divalproex <> Tiagabine Hydrochloride
Relevance: 25.04.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Tiagabine has been reported to cause a 10% decrease in serum valproate concentrations. Additionally, valproic acid decreased tiagabine protein binding in vitro from 96.3% to 94.4% which resulted in a 40% increase in free tiagabine levels. The clinical significance of either interaction is unknown. However, clinical and/or laboratory monitoring for evidence of altered effect of both drugs is recommended if this combination is used.

References
  • "Product Information. Gabitril (tiagabine)." Abbott Pharmaceutical, Abbott Park, IL.
Divalproex

Generic Name: divalproex sodium

Brand name: Depakote ER, Depakote Sprinkles, Depakote, Depakene, Depacon

Synonyms: Divalproex sodium

Tiagabine Hydrochloride

Generic Name: tiagabine

Brand name: Gabitril

Synonyms: Tiagabine, TiaGABine

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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