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Divalproex and Tolbutamide

Determining the interaction of Divalproex and Tolbutamide and the possibility of their joint administration.

Check result:

Divalproex <> Tolbutamide

Relevance: 25.04.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Valproate may displace tolbutamide from plasma protein-binding sites. However, the clinical significance of the increased refraction of tolbutamide in plasma has not been determined.

References

Fernandez MC, Erill S, Lucena MI, et al "Serum protein binding of tolbutamide in patients treated with antileptic drugs." Clin Pharmacokinet 10 (1985): 451-5

Divalproex

Generic Name: divalproex sodium

Brand name: Depakote ER, Depakote Sprinkles, Depakote, Depakene, Depacon

Synonyms: Divalproex sodium

What is Divalproex?

Tolbutamide

Generic Name: tolbutamide

Brand name: Orinase, Orinase Diagnostic, Tol-Tab

Synonyms: TOLBUTamide

What is Tolbutamide?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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