Divalproex and Vorinostat

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using divalproex sodium together with vorinostat can cause you to bleed more easily. You may need a dose adjustment in addition to special testing of your blood. Call your doctor promptly if you have any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR CLOSELY: Severe thrombocytopenia and gastrointestinal bleeding have been reported during concomitant use of vorinostat and other histone deacetylase (HDAC) inhibitors such as valproic acid, presumably due to additive pharmacodynamic effects.

MANAGEMENT: Blood cell counts, including platelets, should be performed every two weeks during the first two months of vorinostat therapy, then monthly thereafter. If abnormalities develop, the dosage should be reduced or therapy discontinued.

Divalproex

Generic Name: divalproex sodium

Brand name: Depakote ER, Depakote Sprinkles, Depakote, Depakene, Depacon

Synonyms: Divalproex sodium

What is Divalproex?

Vorinostat

Generic Name: vorinostat

Brand name: Zolinza

Synonyms: n.a.

What is Vorinostat?