Divalproex Delayed Release and Fluoxetine Capsules
Determining the interaction of Divalproex Delayed Release and Fluoxetine Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Individual case reports suggest that fluoxetine may increase valproate levels, perhaps by inhibiting the hepatic metabolism of valproate. Another study of two patients suggests that valproate may enhance the therapeutic effects of fluoxetine. The mechanism is unknown. Patients should be monitored for altered pharmacologic effects and increased valproic acid levels if these drugs are administered concomitantly.
- Corrigan FM "Sodium valproate augmentation of fluoxetine or fluvoxamine effects." Biol Psychiatry 31 (1992): 1178-9
- Sovner R, Davis JM "A potential drug interaction between fluoxetine and valproic acid." J Clin Psychopharmacol 11 (1991): 389
Generic Name: divalproex sodium
Brand name: Depakote ER, Depakote Sprinkles, Depakote, Depakene, Depacon
Synonyms: Divalproex sodium, Divalproex
Generic Name: fluoxetine
Brand name: Prozac, Prozac Weekly, PROzac Pulvules, Sarafem, Rapiflux, Selfemra
Synonyms: Fluoxetine, FLUoxetine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Divalproex Delayed Release-Fluoxetine Capsules and Tablets
- Divalproex Delayed Release-Fluoxetine Capsules and Tablets (PMDD)
- Divalproex Delayed Release-Fluoxetine Delayed-Release Capsules
- Divalproex Delayed Release-Fluoxetine Hydrochloride
- Divalproex Delayed Release-Fluoxetine Solution
- Divalproex Delayed Release-Fluoxiv Cream
- Fluoxetine Capsules-Divalproex Delayed Release Tablets
- Fluoxetine Capsules-Divalproex Extended Release
- Fluoxetine Capsules-Divalproex Long-Acting Tablets
- Fluoxetine Capsules-Divalproex sodium
- Fluoxetine Capsules-Divalproex Sprinkle
- Fluoxetine Capsules-Divalproex Sprinkle Capsules