Divalproex sodium and Nifedical XL
Determining the interaction of Divalproex sodium and Nifedical XL and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Divalproex sodium may increase the blood levels and effects of NIFEdipine. You may be more likely to experience serious side effects such as irregular heart rhythm, fluid retention, swelling, heart failure, and excessively low blood pressure. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. You should seek medical attention if you experience dizziness or fainting; sudden, unexplained weight gain; swelling of the hands, ankles, or feet; chest pain; or difficulty breathing during treatment with these medications. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Valproic acid and its derivatives may theoretically increase the effects of nifedipine by decreasing its first-pass metabolism and increasing bioavailability. The clinical significance is unknown.
MANAGEMENT: It is recommended to monitor blood pressure and consider dose reductions of nifedipine during concomitant therapy.
- Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
- "Product Information. Adalat (nifedipine)." Bayer, West Haven, CT.
- Cerner Multum, Inc. "Australian Product Information." O 0
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: divalproex sodium
Brand name: Depakote ER, Depakote Sprinkles, Depakote, Depakene, Depacon
Synonyms: Divalproex
Generic Name: nifedipine
Brand name: Adalat CC, Afeditab CR, Nifediac CC, Nifedical XL, Procardia, Procardia XL, Adalat
Synonyms: Nifedical XL (Oral)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Divalproex sodium-Nifedipine
- Divalproex sodium-Nifedipine Capsules
- Divalproex sodium-Nifedipine Extended-Release Tablets
- Divalproex sodium-Niferex
- Divalproex sodium-Niferex Elixir
- Divalproex sodium-Night Cast R Topical
- Nifedical XL-Divalproex Sprinkle
- Nifedical XL-Divalproex Sprinkle Capsules
- Nifedical XL-Divigel
- Nifedical XL-Divigel 0.75 mg/packet for use on skin
- Nifedical XL-Divigel Transdermal
- Nifedical XL-Divista