Divalproex Sprinkle and PCE Dispertab
Determining the interaction of Divalproex Sprinkle and PCE Dispertab and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before using erythromycin, tell your doctor if you also use divalproex sodium. This combination may cause restlessness, seizures, tremors, slurred speech, staggering walk, and feeling light-headed or fainting. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or special tests in order to safely take both medications together. Avoid driving until you know how the medications will affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: A single case has been reported in which a patient developed seizures associated with elevated blood valproate levels after erythromycin was added to a stable valproate regimen. The seizures and elevated valproate levels resolved after both drugs were withheld. The patient subsequently tolerated her usual valproate dosage. The mechanism is suspected to be inhibition of the hepatic metabolism of valproate.
MANAGEMENT: While more data are needed, clinicians are encouraged to be aware that this interaction is possible when macrolide antimicrobial agents and valproate are coadministered. Patients should be advised to notify their physicians if they experience weakness, fatigue, confusion, ataxia, increased seizures, nausea, or vomiting.
- Redington K, Wells C, Petito F "Erythromycin and valproate interaction." Ann Intern Med 116 (1992): 877-8
Generic Name: divalproex sodium
Brand name: Depakote ER, Depakote Sprinkles, Depakote, Depakene, Depacon
Synonyms: Divalproex sodium, Divalproex
Generic Name: erythromycin
Brand name: EES. Granules, EES-400 Filmtab, EryPed 200, EryPed 400, Ery-Tab, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, PCE Dispertab, E. E. S, EryPed, Erythrocin, Erythromycin Filmtabs, Erythromycin Lactobionate - IV
Synonyms: PCE Dispertab (Oral), PCE, PCE (Oral)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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