Dofetilide and Lanoxin Pediatric Intravenous

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using digoxin together with dofetilide may affect the rhythm of your heart. Call your doctor if you have symptoms of irregular heartbeat, chest tightness, blurred vision or nausea. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Concomitant administration of digoxin and dofetilide has been associated with a higher occurrence of torsade de pointes arrhythmia than dofetilide alone. It is not clear whether this finding represents an interaction between the drugs or the presence of more severe structural heart disease, a known risk factor for arrhythmia, in patients on digoxin. However, no increase in mortality has been observed in patients taking this combination. In a pharmacokinetic study, dofetilide (250 mcg twice daily for 5 days) had no significant effect on the steady-state pharmacokinetics of digoxin (250 mcg once daily) in healthy volunteers compared to placebo.

MANAGEMENT: Clinicians should be aware of the potential for increased risk of torsade de pointes when dofetilide is administered in patients treated with digoxin.

Dofetilide

Generic Name: dofetilide

Brand name: Tikosyn

Synonyms: n.a.

What is Dofetilide?

Lanoxin Pediatric Intravenous

Generic Name: digoxin

Brand name: Lanoxin, Digitek, Digox, Lanoxicaps, Cardoxin

Synonyms: Lanoxin

What is Lanoxin Pediatric Intravenous?