Dofetilide and Lurasidone Hydrochloride

• Generic Name: dofetilide
• Dosage Forms: n.a.
• Other Brand Names: Tikosyn

Dofetilide is a heart rhythm medicine, also called an antiarrhythmic.

Dofetilide is used to help keep the heart beating normally in people with certain heart rhythm disorders of the atrium (the upper chambers of the heart that allow blood to flow into the heart). Dofetilide is used in people with atrial fibrillation or atrial flutter.

Dofetilide may also be used for purposes not listed in this medication guide.

• Generic Name: lurasidone
• Dosage Forms: n.a.
• Other Brand Names: Latuda

Acute treatment of schizophrenia in adults.

American Psychiatric Association (APA) considers most atypical antipsychotic agents first-line drugs for management of the acute phase of schizophrenia (including first psychotic episodes).

Patients who do not respond to or tolerate one drug may be successfully treated with an agent from a different class or with a different adverse effect profile.

Treatment (alone or in combination with lithium or valproate) of major depressive episodes associated with bipolar I disorder (bipolar depression).

Appears less likely to cause weight gain and to adversely affect metabolic parameters than some other atypical antipsychotic agents (e.g., olanzapine, quetiapine). Consider as alternative therapy in patients at higher risk of metabolic abnormalities (e.g., those with diabetes mellitus or hyperlipidemia).

Manufacturer states that efficacy of lurasidone in the treatment of mania associated with bipolar disorder has not been established.