Dofetilide and Sporanox

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using itraconazole and dofetilide is not recommended. Taking these drugs together can affect the rhythm of your heart. Call your doctor if you have symptoms of irregular heartbeat pattern, chest tightness, blurred vision or nausea. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Based on in vitro data, coadministration with itraconazole may increase the plasma concentrations of dofetilide. The proposed mechanism is itraconazole inhibition of CYP450 3A4, the isoenzyme partially responsible for the metabolic clearance of dofetilide. The use of dofetilide has been associated with prolongation of the QT interval, thus elevated plasma levels of the drug may potentiate the risk of ventricular arrhythmias such as ventricular tachycardia and torsade de pointes as well as cardiac arrest and sudden death.

MANAGEMENT: Given the potential for serious and life-threatening adverse cardiac events associated with increased plasma levels of dofetilide, the concomitant use with itraconazole is considered contraindicated.

Dofetilide

Generic Name: dofetilide

Brand name: Tikosyn

Synonyms: n.a.

What is Dofetilide?

Sporanox

Generic Name: itraconazole

Brand name: Sporanox, Onmel, Sporanox PulsePak, Tolsura

Synonyms: n.a.

What is Sporanox?