Dolasetron Injection and Tagamet HB

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Blood levels of hydrodolasetron, the major active metabolite of dolasetron, were increased 24% when given concomitantly with cimetidine. The mechanism is thought to be inhibition of the metabolism of hydrodolasetron by cimetidine. The clinical significance is unknown but may be low because hydrodolasetron is eliminated by multiple routes. The clinician may consider monitoring the patient more closely for dolasetron toxicity (hypotension, dizziness, arrhythmias) if this combination is used.

Dolasetron Injection

Generic Name: dolasetron

Brand name: Anzemet

Synonyms: Dolasetron

What is Dolasetron Injection?

Tagamet HB

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: n.a.

What is Tagamet HB?