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Dolobid and Ratio-Indomethacin

Determining the interaction of Dolobid and Ratio-Indomethacin and the possibility of their joint administration.

Check result:

Dolobid <> Ratio-Indomethacin

Relevance: 08.11.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using indomethacin together with diflunisal. This can increase the effects of indomethacin. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Concomitant administration of diflunisal may increase serum indomethacin concentrations by up to two- to threefold and increase the risk of toxicity such as gastrointestinal and central nervous system side effects. The mechanism is unknown, but may involve competition for the same metabolic and secretory pathways, and/or inhibition of glucuronidation by diflunisal. The renal clearance of indomethacin and its conjugate are also significantly reduced. Fatal gastrointestinal hemorrhage has been reported.

MANAGEMENT: The manufacturer recommends that this combination should be avoided.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Eriksson LO, Wahlin-Boll E, Liedholm H, et al "Influence of chronic diflunisal treatment on the plasma levels, metabolism and excretion of indomethacin." Eur J Clin Pharmacol 37 (1989): 7-15
"Product Information. Dolobid (diflunisal)." Merck & Co, Inc, West Point, PA.
Cerner Multum, Inc. "Australian Product Information." O 0
Van Hecken A, Verbesselt R, Tjandra-Maga TB, De Schepper PJ "Pharmacokinetic interaction between indomethacin and diflunisal." Eur J Clin Pharmacol 36 (1989): 507-12

Dolobid

Generic Name: diflunisal

Brand name: Dolobid

Synonyms: n.a.

What is Dolobid?

Ratio-Indomethacin

Generic Name: indomethacin

Brand name: Indocin, Indocin SR, Tivorbex

Synonyms: Indomethacin

What is Ratio-Indomethacin?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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