Dolorex and Leader Heartburn Relief
Determining the interaction of Dolorex and Leader Heartburn Relief and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Animal studies and some limited human studies have suggested that cimetidine may decrease the potential hepatotoxic effects of acetaminophen. The mechanism may be related to reductions in the rate at which reactive intermediate metabolites are formed. Not all studies have confirmed the occurrence of this interaction. No alterations in dosage are necessary.
- Slattery JT, McRorie TI, Reynolds R, et al "Lack of effect of cimetidine on acetaminophen disposition in humans." Clin Pharmacol Ther 46 (1989): 591-7
- Dalhoff K, Poulsen HE "Inhibition of acetaminophen oxidation by cimetidine and the effects on glutathione and activated sulphate synthesis rates." Pharmacol Toxicol 73 (1993): 215-8
- Mitchell MC, Schenker S, Speeg KV "Selective inhibition of acetaminophen oxidation and toxicity by cimetidine and other histamine H2-receptor antagonists in vivo and in vitro in the rat and in man." J Clin Invest 73 (1984): 383-91
- Vendemiale G, Altomare E, Trizio T, Leandro G, Manghisi OG, Albano O "Effect of acute and chronic cimetidine administration on acetaminophen metabolism in humans." Am J Gastroenterol 82 (1987): 1031-4
Generic Name: acetaminophen / phenyltoloxamine
Brand name: Dologesic, Dologesic DF, Aceta-Gesic, Percogesic, Major-gesic, Phenylgesic, Apagesic, Duogesic, Phenagesic, Genasec, Q-Gesic, Uni-Perr, Vitoxapap, Flextra-DS, Dolorex, RhinoFlex, Relagesic, Staflex, Alpain, Flextra-650, Acuflex, Hyflex-650, Hyflex-DS, Lagesic, RhinoFlex 650, Q Flex, Vistra, BeFlex, BP Poly-650, Zgesic, Ali-Flex, Dologen, Flextra DS
Synonyms: Acetaminophen and phenyltoloxamine
Generic Name: cimetidine
Brand name: Tagamet HB, Tagamet
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Dolorex-Leader Nicotine Polacrilex gum, lozenge
- Dolorex-Leader Sleep Aid
- Dolorex-Ledipasvir and sofosbuvir
- Dolorex-Ledipasvir and Sofosbuvir Tablets
- Dolorex-Leena
- Dolorex-Lefamulin
- Leader Heartburn Relief-Dolorex Forte
- Leader Heartburn Relief-Dolotranz
- Leader Heartburn Relief-Dolutegravir
- Leader Heartburn Relief-Dolutegravir 10 mg
- Leader Heartburn Relief-Dolutegravir 25 mg and 50 mg
- Leader Heartburn Relief-Dolutegravir and lamivudine