Dolutegravir and rilpivirine and Ferretts
Determining the interaction of Dolutegravir and rilpivirine and Ferretts and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Dolutegravir and ferrous fumarate should not be taken orally at the same time. Products that contain aluminum, calcium, iron, magnesium and/or other minerals may interfere with the absorption of dolutegravir and reduce its effectiveness in treating HIV infection. You should take dolutegravir at least two hours before or six hours after the ferrous fumarate dose. Talk to your doctor if you have any questions or concerns, or if you have trouble separating the dosing times. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: Coadministration with medications containing polyvalent cations such as aluminum, calcium, iron, or magnesium may decrease the oral bioavailability of dolutegravir. The mechanism of interaction has not been established. In 16 study subjects, administration of a single 50 mg dose of dolutegravir simultaneously with an antacid (Maalox) decreased dolutegravir peak plasma concentration (Cmax), systemic exposure (AUC) and trough plasma concentration (Cmin; 24 hours post-dose) by 72%, 74% and 74%, respectively, compared to administration without the antacid. When the antacid was administered 2 hours after dolutegravir, the Cmax, AUC and Cmin of dolutegravir decreased by just 18%, 26% and 30%, respectively. Administration of single-dose dolutegravir simultaneously with a multivitamin (One-A-Day) decreased the Cmax, AUC and Cmin of dolutegravir by 35%, 33% and 32%, respectively.
MANAGEMENT: Dolutegravir should be administered 2 hours before or 6 hours after medications containing polyvalent cations such as antacids, laxatives, or mineral supplements.
- "Product Information. Tivicay (dolutegravir)." ViiV Healthcare, Research Triangle Park, NC.
Generic Name: dolutegravir / rilpivirine
Brand name: Juluca
Synonyms: Dolutegravir and Rilpivirine
Generic Name: ferrous fumarate
Brand name: Ferretts Iron, Ferrocite, Ferro-Sequels, Hemocyte, Ircon, Femiron, Fumasorb, Nephro-Fer, Feostat, Ferrimin 150
Synonyms: Ferretts Iron
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Dolutegravir and rilpivirine-Ferretts Iron
- Dolutegravir and rilpivirine-Ferrex 150 Forte
- Dolutegravir and rilpivirine-Ferrex 150 Forte Plus
- Dolutegravir and rilpivirine-Ferrex 28
- Dolutegravir and rilpivirine-Ferrex-150
- Dolutegravir and rilpivirine-Ferric carboxymaltose
- Ferretts-Dolutegravir Sodium
- Ferretts-Dolutegravir Sodium And Lamivudine
- Ferretts-Dolutegravir Sodium and Rilpivirine Hydrochloride
- Ferretts-Dom-Etoposide
- Ferretts-Donatuss DC Syrup
- Ferretts-Donatussin