Dolutegravir and rilpivirine and Protonix (Pantoprazole Delayed-Release Granules)
Determining the interaction of Dolutegravir and rilpivirine and Protonix (Pantoprazole Delayed-Release Granules) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using rilpivirine together with pantoprazole is not recommended. By reducing the acidity level in the stomach, pantoprazole can decrease the absorption and blood levels of rilpivirine and make the medication less effective against HIV. Talk to a healthcare provider if you have any questions or concerns. Your doctor or pharmacist may be able to recommend alternatives that do not interact (or interact to a lesser extent) if you require treatment for stomach acid or ulcer while you are being treated with rilpivirine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:CONTRAINDICATED: Coadministration with proton pump inhibitors may significantly decrease the oral bioavailability of rilpivirine. The proposed mechanism involves a pH-dependent reduction in dissolution and absorption of rilpivirine, which is poorly soluble over a wide pH range. When a single 150 mg dose of rilpivirine was administered with omeprazole 20 mg once daily to 16 study subjects, mean rilpivirine peak plasma concentration (Cmax), systemic exposure (AUC) and trough plasma concentration (Cmin) decreased by 40%, 40% and 33%, respectively, compared to rilpivirine administered alone. No clinically significant changes in omeprazole Cmax and AUC were observed.
MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiretroviral drug levels, concomitant use of rilpivirine with proton pump inhibitors is considered contraindicated.
- "Product Information. Edurant (rilpivirine)." Tibotec Pharmaceuticals, Titusville, NJ.
Generic Name: dolutegravir / rilpivirine
Brand name: Juluca
Synonyms: Dolutegravir and Rilpivirine
Generic Name: pantoprazole
Brand name: Protonix, Protonix IV
Synonyms: Protonix
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Dolutegravir and rilpivirine-Protonix (Pantoprazole Delayed-Release Tablets)
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- Dolutegravir and rilpivirine-Protonix oral/injection
- Dolutegravir and rilpivirine-Protonix Tablets
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