Dolutegravir and rilpivirine and Tricitrasol
Determining the interaction of Dolutegravir and rilpivirine and Tricitrasol and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:By reducing the acidity level in the stomach, sodium citrate can decrease the absorption and blood levels of rilpivirine and make the medication less effective against HIV. To minimize the risk of interaction, sodium citrate should be taken at least 2 hours before or 4 hours after you take rilpivirine. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: Coadministration with antacids may decrease the oral bioavailability of rilpivirine. The proposed mechanism involves a pH-dependent reduction in dissolution and absorption of rilpivirine, which is poorly soluble over a wide pH range. The interaction has not been studied specifically with antacids, but has been reported for H2-receptor antagonists and proton pump inhibitors.
MANAGEMENT: To minimize the risk of reduced viral susceptibility and resistance development associated with subtherapeutic levels of rilpivirine, antacids or other medications that contain antacids (e.g., didanosine buffered tablets or pediatric oral solution) should be administered at least 2 hours before or 4 hours after the rilpivirine dose.
- "Product Information. Edurant (rilpivirine)." Tibotec Pharmaceuticals, Titusville, NJ.
Generic Name: dolutegravir / rilpivirine
Brand name: Juluca
Synonyms: Dolutegravir and Rilpivirine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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